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Ved akutt isjias er det vesentlig at person respekterer smerten og holder seg i ro. De fleste som fileår uutholdelige smerter eller lammelser har som regel merket symptomer i lang tid uten å ta dette alvorlig.Fra et biokjemisk synspunkt har disse medisinene en lignende virkningsmekanisme. De hemmer flere mellomledd som involverer cyklooksygenasev

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